Clinical Studies on OCV

Where do we stand on eliminating cholera from the globe?

Mohammad Ali, PhD

Senior Scientist | Johns Hopkins Bloomberg School of Public Health
OCV Administration in Kolkata, India by the IVI-NICED Cholera Team (2006)

OCV Administration in Kolkata India by IVI-NICED Cholera Team (2006)

Cholera is one of the most feared diseases and many people die of the disease each year. The disease was first noted by British troops near Jessore, India in 1817. By 1832, it had spread across Russia and Germany to England. [1] During this time, cholera was recognized as a European disease, [2] but with improvements in sanitation and the provision of safe drinking water, the disease was eliminated from  Europe.

5 Year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: A cluster-randomised, double-blind, placebo-controlled trial

Article published in The Lancet on 17-Oct-2013 by Bhattacharya, S. K. et al.


Efficacy and safety of a two-dose regimen of bivalent killed whole-cell oral cholera vaccine (Shantha Biotechnics, Hyderabad, India) to 3 years is established, but long-term efficacy is not. We aimed to assess protective efficacy up to 5 years in a slum area of Kolkata, India.

Effectiveness of an oral cholera vaccine in Zanzibar: Findings from a mass vaccination campaign and observational cohort study

Article published in The Lancet Infectious Diseases on 4-Sep-2012 by Khatib, A. M. et al.

BACKGROUND: Zanzibar, in east Africa, has been severely and repeatedly affected by cholera since 1978. We assessed the effectiveness of oral cholera vaccination in high-risk populations in the archipelago to estimate the indirect (herd) protection conferred by the vaccine and direct vaccine effectiveness.